The association between rs2910164 in miR-146a and hepatocellular carcinoma risk: a case-control study
نویسندگان
چکیده
Several studies reported the association between the miR-146a rs2910164 polymorphism and Hepatocellular Carcinoma (HCC) risk, but the results were controversial. Thus, we did a case-control study to determine the association between miR-146a rs2910164 polymorphism and HCC risk. This study included 188 HCC cases and 186 controls. HCC was diagnosed by liver biopsy. Healthy individuals undergoing routine medical examination without any medical illness. CG genotype in HCC patients with miR-146a rs2910164 polymorphism increased the risk of HCC (OR=1.99, 95% CI 1.27-3.11, P=0.003). CC genotype in HCC patients with miR-146a rs2910164 polymorphism also showed an increased risk of HCC (OR=3.30, 95% CI 1.72-6.32, P=0.0003). In addition, patients with CG and CC had significant increased risk of HCC (OR=2.24, 95% CI 1.47-3.42, P=0.0002) in dominant model. Further, patients with CC genotype also had increased risk of HCC (OR=2.29, 95% CI 1.25-4.19, P=0.0002) in recessive model. The C allele seemed to be a risk factor of HCC (OR=1.88, 95% CI 1.39-2.54, P<0.0001). In conclusion, the study suggested that miR-146a rs2910164 polymorphism was significantly associated with HCC risk.
منابع مشابه
ASSOCIATION STUDY OF MIR-146A RS2910164 AND RS57095329 POLYMORPHISMS WITH RISK OF BEHCET’S DISEASE
Background & Aims: Behcet's disease (BD) is an autoimmune disease that usually occurs with oral, genital and ocular ulcers. The cause of this disease is unknown and environmental, genetic and immunological factors contribute to its development. In the present study, the relation between rs2910164 and rs57095329 polymorphisms of miR146a gene with the potential for BD was investigated in Iranian ...
متن کاملAssociation of miR-146a rs2910164 and miR-27a rs895819 polymorphisms with type 2 diabetes susceptibility: A Meta-Analysis
Background and Aim: Several investigations have evaluated the association of miR-146a rs2910164 and miR-27a rs895819 single-nucleotide polymorphisms with susceptibility to type 2 diabetes (T2D). However, the findings are conflicting and inconclusive. Therefore, this meta-analysis performed to investigate the association between these polymorphisms and T2D risk. Methods: Studies were identifie...
متن کاملThe Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population
BACKGROUND Emerging evidence has shown that microRNAs (miRNAs) participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) located in the miRNAs may influence the function of mature miRNAs and then affect the processing of carcinogenesis. It has been suggested that two common SNPs rs2910164 in miR-146a and rs3746444 in miR-499 are associated with ...
متن کاملMiR-146a rs2910164 polymorphism is associated with hepatocellular carcinoma: a meta-analysis.
Results of published studies on the association between the miR-146a rs2910164 polymorphism and the risk of hepatocellular carcinoma (HCC) were inclusive. We performed a meta-analysis. A literature research was conducted using PubMed, Cochrane Library, Ovid, Embase, Wanfang and China National Knowledge Infrastructure (CNKI) databases, to identify studies. Statistical analyses were conducted in ...
متن کاملMiR-146a rs2910164 polymorphism and head and neck carcinoma risk: a meta-analysis based on 10 case-control studies
Two recent meta-analyses have been conducted on the relationship between miR-146a polymorphism (rs2910164) and head and neck cancer (HNC) risk. However, they have yielded conflicting results. Hence, the aim of the present study was to conduct a quantitative updated meta-analysis addressing this subject. Eligible studies up to Sep 2016 were retrieved and screened from the bio-databases and then ...
متن کامل